Hypoglycemic Activity of Carica papaya Leaf Aqueous Extract in Normal and Diabetic Mice

Abstract

The hypoglycemic effect of aqueous extract of Carica papaya leaves was investigated on alloxan monohydrate induced diabetic mice. The blood glucose levels were measured at 0, 2, 4 and 6 h after the treatment. The aqueous extract of C. papaya (250 mg/kg) reduced the blood glucose of normal mice from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (P<0.05). It also significantly lowered blood glucose level in alloxan induced diabetic mice from 331.67±4.90 to 130.33±6.53 mg/dl, 6h after oral administration of the extract (P<0.05).