Hypocholesterolemic Effect of Nauclea Latifolia Fruit on Glucose Changes and Lipid Profile of Alloxan Induced Diabetes in Albino Rats

Abstract

This study is aimed at determining the efficacy of some of the claims and to evaluate the hypocholesterolemic properties of N. latifolia in comparison with metformin in diabetic Albino rats. The objectives are to evaluate the phytochemistry and the effect of N. latifolia on lipid profile in alloxan induced diabetes in comparism with metformin as drug control. Thirty male albino Wister rats weighing 60g-90g were used. The rats were divided into six groups of five animals each. Group 1(normal control, group 2 (-ve control), group 3 (+ve control), group 4, 5 and 6 were given 10%, 30% and 60% of the fruit as feed supplement as treatment. The abnormal lipid profiles and lipoprotein oxidation especially, Low density lipoprotein cholesterol is more common in diabetics and is aggravated with poor glycaemia control. In this study, hypoglycemic and hypocholesterolemic properties of Nauclea latifolia fruits were investigated. Fruit sample was administered on percentage basis to alloxan - induced diabetic rats once daily for a period of twenty one days. Their blood glucose level was measured every three days while Lipid profile was assayed at the end of the experiment. The fruit sample significantly reduced (p<0.05) the fasting blood glucose levels compared to the diabetic control and was discovered to be dosage dependent. Total Cholesterol, very low density lipoprotein, triglycerides and Low Density Lipoprotein Cholesterol was reduced significantly (p<0.05) by Nauclea latifolia fruit dose - dependently. In diabetics, there is a decrease in the level of electrolytes as a result of osmotic diuresis with subsequent loss of water and electrolytes induced by glycosuria.