Development Nanostructured Lipid Carriers (Nlc) Loaded Resveratrol with Different Combination of Soybean Oil and Oleic Acid

Abstract

Resveratrol is a potential antioxidant to improve skin aging. However, resveratrol has the disadvantage of being insoluble in water and unstable to light, for this reason is made the delivery system of lipid nanostructure carrier that has the ability to protect unstable compounds that can increase the stability of active ingredients during storage period. The purpose of this study was to formulate resveratrol nanostructure lipid carrier (NLC) and evaluate the stability of nanoparticles in maintaining stability during storage. The NLC formula is made with different comparative concentrations of liquid lipids, soy bean oil and oleic acid (3: 1, 2: 2, 1: 3) using the High Shear Homogenization method. Characterization is then carried out. NLC includes particle size, potential zeta, polydispersity index, viscosity, PH, entrapment efficiency of resveratrol, FTIR, NLC morphology and storage stability test for 60 days with particle size parameters, polydispersity index and PH. NLC resveratrol with a ratio of 1: 3 shows spherical morphology with an average particle size of 304.36 ± 35.82 nm, polydispersity index 0.243 ± 0.03, zeta potential -47.9 ± 1.26 and entrapment efficiency 95.08 ± 0.09, viscosity 420.00 ± 16.3. In the stability test of NLC-F3 with a ratio of 1: 3 is stable for 60 days of storage including particle size, polidispersity index and PH.